U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Multidrug-resistant tuberculosis

MedGen UID:
60163
Concept ID:
C0206526
Disease or Syndrome
Synonyms: MDR Tuberculosis; Multi-Drug Resistant Tuberculosis; Multidrug-Resistant Tuberculosis; Tuberculosis, MDR; Tuberculosis, Multi Drug Resistant; Tuberculosis, Multi-Drug Resistant; Tuberculosis, Multidrug Resistant; Tuberculosis, Multidrug-Resistant
SNOMED CT: Multidrug resistant tuberculosis (423092005)
 
Monarch Initiative: MONDO:0005861

Definition

Tuberculosis disease that is caused by a multidrug-resistant strain of Mycobacterium tuberculosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultidrug-resistant tuberculosis

Professional guidelines

PubMed

Suárez I, Fünger SM, Kröger S, Rademacher J, Fätkenheuer G, Rybniker J
Dtsch Arztebl Int 2019 Oct 25;116(43):729-735. doi: 10.3238/arztebl.2019.0729. PMID: 31755407
Lange C, Dheda K, Chesov D, Mandalakas AM, Udwadia Z, Horsburgh CR Jr
Lancet 2019 Sep 14;394(10202):953-966. doi: 10.1016/S0140-6736(19)31882-3. PMID: 31526739Free PMC Article
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838

Recent clinical studies

Etiology

Chopra KK, Matta S, Arora VK
Indian J Tuberc 2022;69 Suppl 2:S202-S204. Epub 2022 Oct 26 doi: 10.1016/j.ijtb.2022.10.022. PMID: 36400509
Pradipta IS, Forsman LD, Bruchfeld J, Hak E, Alffenaar JW
J Infect 2018 Dec;77(6):469-478. Epub 2018 Oct 16 doi: 10.1016/j.jinf.2018.10.004. PMID: 30339803
Hargreaves S, Lönnroth K, Nellums LB, Olaru ID, Nathavitharana RR, Norredam M, Friedland JS
Clin Microbiol Infect 2017 Mar;23(3):141-146. Epub 2016 Sep 23 doi: 10.1016/j.cmi.2016.09.009. PMID: 27665703
Millard J, Ugarte-Gil C, Moore DA
BMJ 2015 Feb 26;350:h882. doi: 10.1136/bmj.h882. PMID: 25721508
Davies PD
J R Soc Med 2001 Jun;94(6):261-3. doi: 10.1177/014107680109400601. PMID: 11387411Free PMC Article

Diagnosis

Hui SYA, Lao TT
Best Pract Res Clin Obstet Gynaecol 2022 Dec;85(Pt A):34-44. Epub 2022 Jul 31 doi: 10.1016/j.bpobgyn.2022.07.006. PMID: 36002371Free PMC Article
Millard J, Ugarte-Gil C, Moore DA
BMJ 2015 Feb 26;350:h882. doi: 10.1136/bmj.h882. PMID: 25721508
Lynch JB
Med Clin North Am 2013 Jul;97(4):553-79, ix-x. doi: 10.1016/j.mcna.2013.03.012. PMID: 23809714
Pontali E, Matteelli A, Migliori GB
Curr Opin Pulm Med 2013 May;19(3):266-72. doi: 10.1097/MCP.0b013e32835f1bf3. PMID: 23422415
Amdekar YK
Indian Pediatr 1998 Aug;35(8):715-8. PMID: 10216564

Therapy

Farhat M, Cox H, Ghanem M, Denkinger CM, Rodrigues C, Abd El Aziz MS, Enkh-Amgalan H, Vambe D, Ugarte-Gil C, Furin J, Pai M
Nat Rev Microbiol 2024 Oct;22(10):617-635. Epub 2024 Mar 22 doi: 10.1038/s41579-024-01025-1. PMID: 38519618
Motta I, Boeree M, Chesov D, Dheda K, Günther G, Horsburgh CR Jr, Kherabi Y, Lange C, Lienhardt C, McIlleron HM, Paton NI, Stagg HR, Thwaites G, Udwadia Z, Van Crevel R, Velásquez GE, Wilkinson RJ, Guglielmetti L; Study group on Mycobacteria (ESGMYC) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Clin Microbiol Infect 2024 Sep;30(9):1107-1114. Epub 2023 Jul 22 doi: 10.1016/j.cmi.2023.07.013. PMID: 37482332
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D'Ambrosio L, Bates M, Kibiki G, Kapata N, Corrah T, Bomanji J, Vilaplana C, Johnson D, Mwaba P, Maeurer M, Zumla A
Clin Infect Dis 2015 Oct 15;61Suppl 3(Suppl 3):S102-18. doi: 10.1093/cid/civ609. PMID: 26409271Free PMC Article

Prognosis

Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes JA, Kampmann B, Graham SM, Dodd PJ, Houben RM, Denholm JT, Sawyer SM, Kranzer K
Lancet Child Adolesc Health 2020 Jan;4(1):68-79. Epub 2019 Nov 18 doi: 10.1016/S2352-4642(19)30337-2. PMID: 31753806Free PMC Article
Ahmad S, Mokaddas E, Al-Mutairi NM
Expert Rev Anti Infect Ther 2018 Sep;16(9):709-721. Epub 2018 Sep 13 doi: 10.1080/14787210.2018.1519393. PMID: 30173588
Kritski A, Andrade KB, Galliez RM, Maciel ELN, Cordeiro-Santos M, Miranda SS, Villa TS, Ruffino Netto A, Arakaki-Sanchéz D, Croda J
Rev Soc Bras Med Trop 2018 Jan-Feb;51(1):2-6. doi: 10.1590/0037-8682-0349-2017. PMID: 29513837
Houben RM, Dodd PJ
PLoS Med 2016 Oct;13(10):e1002152. Epub 2016 Oct 25 doi: 10.1371/journal.pmed.1002152. PMID: 27780211Free PMC Article
Bai KJ, Wu IH, Yu MC, Chiang IH, Chiang CY, Lin TP, Lee YC, Luh KT
Respirology 1998 Dec;3(4):261-6. doi: 10.1111/j.1440-1843.1998.tb00132.x. PMID: 10201053

Clinical prediction guides

Ivanova O, Hoffmann VS, Lange C, Hoelscher M, Rachow A
Eur Respir Rev 2023 Jun 30;32(168) Epub 2023 Apr 19 doi: 10.1183/16000617.0221-2022. PMID: 37076175Free PMC Article
Günther G, Ruswa N, Keller PM
Curr Opin Pulm Med 2022 May 1;28(3):211-217. Epub 2022 Feb 25 doi: 10.1097/MCP.0000000000000866. PMID: 35220372Free PMC Article
Nahid P, Mase SR, Migliori GB, Sotgiu G, Bothamley GH, Brozek JL, Cattamanchi A, Cegielski JP, Chen L, Daley CL, Dalton TL, Duarte R, Fregonese F, Horsburgh CR Jr, Ahmad Khan F, Kheir F, Lan Z, Lardizabal A, Lauzardo M, Mangan JM, Marks SM, McKenna L, Menzies D, Mitnick CD, Nilsen DM, Parvez F, Peloquin CA, Raftery A, Schaaf HS, Shah NS, Starke JR, Wilson JW, Wortham JM, Chorba T, Seaworth B
Am J Respir Crit Care Med 2019 Nov 15;200(10):e93-e142. doi: 10.1164/rccm.201909-1874ST. PMID: 31729908Free PMC Article
Shingadia D
Ther Adv Respir Dis 2012 Jun;6(3):161-71. Epub 2012 Feb 23 doi: 10.1177/1753465812436662. PMID: 22361927
Sharma SK, Mohan A
Indian J Med Res 2004 Oct;120(4):354-76. PMID: 15520486

Recent systematic reviews

Salari N, Kanjoori AH, Hosseinian-Far A, Hasheminezhad R, Mansouri K, Mohammadi M
Infect Dis Poverty 2023 May 25;12(1):57. doi: 10.1186/s40249-023-01107-x. PMID: 37231463Free PMC Article
Ivanova O, Hoffmann VS, Lange C, Hoelscher M, Rachow A
Eur Respir Rev 2023 Jun 30;32(168) Epub 2023 Apr 19 doi: 10.1183/16000617.0221-2022. PMID: 37076175Free PMC Article
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Sultana ZZ, Hoque FU, Beyene J, Akhlak-Ul-Islam M, Khan MHR, Ahmed S, Hawlader DH, Hossain A
BMC Infect Dis 2021 Jan 11;21(1):51. doi: 10.1186/s12879-020-05749-2. PMID: 33430786Free PMC Article
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...